CATALOG # 1115
Amount 100 mg
Price $140.00
  • Catalog #:1115
  • Scientific Name:5-alpha-Cholestane
  • Common Name:5-alpha-Cholestane
  • Empirical Formula:C27H48
  • CAS#481-21-0
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:373
  • Unit:100 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:GC
  • Solubility:chloroform, ethyl ether, hexane
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    5-alpha-Cholestane is the non-hydroxy, hydrogenated form of cholesterol and is useful as an internal standard for studies involving sterols.1 Cholesterol is a sterol that is essential for all animal life, being critical for membrane permeability and fluidity and for many cellular functions. It is a sterol that is both synthesized in animals and also acquired from the diet. Phytosterols have been found to compete with cholesterol for absorption in the intestinal tract which results in a reduction of cholesterol absorption.2 Plant sterols are important components of membranes and have a particular role in the plasma membrane, mitochondrial outer membrane, and endoplasmic reticulum. Plant sterols will complex with glycosphingolipids in raft-like sub-domains and can affect many cellular functions including membrane fluidity, permeability, activity of membrane-bound enzymes, cellular differentiation, cellular signaling, and cellular proliferation. Plant sterols have been used extensively in humans to attempt to lower cholesterol and treat certain cancers.3

    1. R. Iborra et al. “Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1” Lipids in Health and Disease, vol. 10 pp. 1-7, 2011
    2. R. Ostlund et al. “Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans” Am J Clin Nutr, Vol. 75(6) pp. 1000-1004, 2002
    3. A. de Jong, J. Plat, R. Mensink “Metabolic effects of plant sterols and stanols (Review)” Journal of Nutritional Biochemistry, Vol. 14:7 pp. 362-369, 2003