Biotinylated Glycosphingolipids

Matreya’s line of biotinylated sphingolipids are ideal for use in sphingolipid research; they take advantage of the strong and specific interaction of biotin with streptavidin and avidin proteins. These sphingolipid analogs contain a biotin label attached to the amine of the sphingosine moiety via a hexanoic acid linker which maintains the sphingolipid’s natural properties. The interaction with streptavidin and avidin proteins makes them extremely useful for binding to substrates,1 ELISA testing,2 and for toxin detection.

References:

  1. A. Mukhopadhyay et al., "Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling" FASEB, Vol. 23(3) pp. 751-763, 2009
  2. A. Pukin et al., "Chemoenzymatic synthesis of biotin-appended analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a for solid-phase applications and improved ELISA tests" Org. Biomol. Chem., Vol. 9(16) pp. 5809-5815, 2011

Catalog #

Cas #

Amount

Price

Image


N-Hexanoyl-biotin-galactosylceramide

N-Hexanoyl-biotin-glucosylceramide

N-Hexanoyl-biotin-sulfatide

N-Hexanoyl-biotin-lactosylceramide

N-Hexanoyl-biotin-monosialoganglioside GM1

N-Hexanoyl-biotin-disialoganglioside GD3