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rac-gamma-Tocopherol

CATALOG # 1073

Specifications

  • Catalog #:1073
  • Scientific Name:rac-gamma-Tocopherol
  • Common Name:7,8-Dimethyltocol
  • Empirical Formula:C28H48O2
  • CAS#7616-22-0
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:417
  • Unit:50 mg/ml, 1ml
  • Solvent:hexane
  • Source:synthetic
  • Purity:TLC 95%; GC 96%; HPLC 96%
  • Analytical Methods:TLC; GC; HPLC; identity confirmed by MS
  • Solubility:methanol, ethanol, hexane, chloroform
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:Yes

Description

Application Notes:

gamma-Tocopherol is the most prevalent form of vitamin E in many seed oils and is the major form of vitamin E in the U.S. diet. gamma-Tocopherol has greater functionability in some processes than other forms of vitamin E such as a greater ability to trap lipophilic electrophiles. In addition, gamma-tocopherol has functions unique from other forms of vitamin E, as in its ability to inhibit cyclooxygenase activity and as a natriuretic.1 It has been suggested that gamma-tocopherol may be able to protect against cardiovascular disease and prostate cancer.2 Vitamin E is involved in immune function, cell signaling, regulation of gene expression, and other metabolic processes. Vitamin E also inhibits lipid oxidation by donating its phenolic hydrogen to lipid free radicals.3 Antioxidant activity in vivo is normally alpha > beta > gamma> delta but the antioxidant potency may depend on various chemical and physical situations.4 The ortho-methyl substitution of the chroman head plays a vital role in the antioxidant activity of tocopherols while the phytyl tail is very important for proper positioning in the biomembranes. The antioxidant properties of vitamin E may delay memory loss in Down’s syndrome patients due to their protection from harmful oxidation caused by excess activity of Superoxide dismutase. Vitamin E is only naturally produced in plants, algae, and some cyanobacteria and is therefore an important dietary nutrient for humans and animals.

References:
1. Q. Jiang et al. “gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention” American Journal of Clinical Nutrition, Vol. 74(6) pp. 714-722, 2001
2. K. Wagner, A. Kamal-Eldin, and I. Elmadfa “Gamma-tocopherol--an underestimated vitamin?” Annals of Nutrition and Metabolism, Vol. 48(3) pp. 169- 188, 2004
3. G. Burton and K. Ingold “Autoxidation of biological molecules. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro”, U. J. Am. Chem. Soc., Vol. 103 pp. 6472-6477, 1981
4. A. Sirikhachornkit et al. “Replacement of alpha-tocopherol by beta-tocopherol enhances resistance to photo-oxidative stress in a xanthophyll-deficient strain of Chlamydomonas reinhardtii”, Eukaryotic Cell, doi:10.1128, 2009
Price $210.00

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