rac-beta-Tocopherol

CATALOG # 1071
Amount 50 mg/ml, 1ml
Price $210.00
Qty
 
rac-beta-Tocopherol
  • Catalog #:1071
  • Scientific Name:rac-beta-Tocopherol
  • Common Name:5,8-Dimethyltocol
  • Empirical Formula:C28H48O2
  • CAS#148-03-8
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:417
  • Unit:50 mg/ml, 1ml
  • Solvent:hexane
  • Source:synthetic
  • Purity:TLC 95%, GC 98%, HPLC 98%
  • Analytical Methods:TLC, GC, HPLC; identity confirmed by MS
  • Solubility:methanol, ethanol, hexane, chloroform
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:Yes
  • Literature References:Application Notes:

    beta-tocopherol is one of the forms of vitamin E, which is well known for its antioxidant activity.1,2 beta-tocopherol, due to its having only one methyl group ortho to the phenolic hydroxyl group, has slightly less antioxidant activity in vivo than alpha-tocopherol which has two ortho-methyl groups. Vitamin E inhibits lipid oxidation by donating its phenolic hydrogen to lipid free radicals.3 Antioxidant activity in vivo is normally lpha>beta>delta>gamma but the antioxidant potency may depend on various chemical and physical situations.4 The ortho-methyl substitution of the chroman head plays a vital role in the antioxidant activity of tocopherols while the phytyl tail is very important for proper positioning in the biomembranes. The antioxidant properties of vitamin E may delay memory loss in Down’s syndrome patients due to their protection from harmful oxidation caused by excess activity of Superoxide dismutase. Vitamin E is only naturally produced in plants, algae, and some cyanobacteria and is therefore an important dietary nutrient for humans and animals.

    References:
    1. Afaf Kamal-Eldin and Lars-Ake Appelqvist The chemistry and antioxidant properties of tocopherols and tocotrienols, Lipids, July; 31 (7): 671-701, 1996
    2. G. W. Burton, and M. G. Traber Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability, Annual Review of Nutrition, July Vol. 10: 357-382, 1990
    3. G. W. Burton and K. Ingold Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro, U. J. Am. Chem. Soc., 103, 6472-6477, 1981
    4. Anchalee Sirikhachornkit, Jai W. Shin, Irene Baroli, and Krishna K. Niyogi Replacement of a -tocopherol by ß -tocopherol enhances resistance to photo-oxidative stress in a xanthophyll-deficient strain of Chlamydomonas reinhardtii, Eukaryotic Cell, doi:10.1128, 2009