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lyso-Sulfatide (NH4+salt)

CATALOG # 1904

Specifications

  • Catalog #:1904
  • Scientific Name:lyso-Sulfatide (NH4+salt)
  • Common Name:Sphingosine-1-galactoside-3-sulfate
  • Empirical Formula:C24H47NO10S•NH3
  • CAS#38621-58-8
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:542
  • Unit:1 mg
  • Solvent:none
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Natural Source:bovine
  • Solubility:chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

Lyso-Sulfatide is ideal for the preparation of well-defined and labeled sulfatides and is excellent for enzyme and metabolism research. Sulfatide is a type of sulfolipid that is found primarily in the central nervous system and is a myelin-specific sphingolipid. A deficiency of sulfatide in white and gray matter has been associated with Alzheimer’s disease and other types of dementia. Apoliprotein E plays an important regulating role in the metabolism of sulfatides.1 A production of anti-sulfatide antibodies in the cerebrospinal fluid, leading to a deficiency in sulfatides, may be a cause of degeneration of the myelin sheath, leading to multiple sclerosis.2 Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent accumulation of sulfatide in neural and visceral tissues.3 An immunomodulatory role for sulfatides has been suggested in the pathogenesis of tuberculosis.

References:
1. H. Cheng, Y. Zhou, D. Holtzman, X. Han “Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease.” Neurobiology of Aging, 2008
2. R. Halder, A. Jahng, I. Maricic and V. Kumar “Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination” Neurochemical Research, Vol. 32(2) pp. 257, 2007
3. P. Whitfield et al. “Characterization of Urinary Sulfatides in Metachromatic Leukodystrophy Using Electrospray Ionization-Tandem Mass Spectrometry” Molecular Genetics and Metabolism, Vol. 73(1) pp. 30, 2001
Price $565.00

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