lyso-Monosialoganglioside GM2 (NH4+ salt), bovine

CATALOG # 1543
Amount 500 µg
Price $600.00
Qty
 
lyso-Monosialoganglioside GM2 (NH4+ salt), bovine
  • Catalog #:1543
  • Scientific Name:lyso-Monosialoganglioside GM2 (NH4+ salt), bovine
  • Common Name:lyso-GM2
  • Empirical Formula:C49H87N3O25 • NH3
  • CAS#94458-61-4
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1118+ NH3
  • Unit:500 µg
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Natural Source:bovine
  • Solubility:chloroform/methanol/DI water, (2:1:0.1); forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application notes:

    Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 GM2 regulates the function of ciliary neurotrophic factor receptors. The accumulation of GM2 (due to a deficiency in beta-hexosaminidase) has characterized Tay-Sachs disease (due to a mutation in the gene HEXA) and Sandhoff disease (due to a mutation in the gene HEXB).4 lyso-GM2 was also found in elevated amounts in brains with Sandhoff and Tay-Sachs disease. Although the origin of lyso-GM2 remains unknown, it is tied with the loss of HEXA. In a study that subjected lyso-GM2 to modified beta-hexasaminidase (Hex B) which hydrolyzes GM2 and associated gangliosides, Hex B was found to strongly influence the lyso-GM2 levels to decrease.5

    Selected References:
    1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
    2. T. Kolter, R. Proia, K. Sandhoff “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002
    3. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003
    4. R. Gravel et al., The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001
    5. T. Kodama, T. Togawa, et. al. “lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease” PLoS ONE, Vol 6, No. 12, 2011