CUSTOMER SERVICE  |  814.355.1030  |  Toll Free: 800.342.3595  |  M-F: 8am-4pm EST/EDT

lyso-Monosialoganglioside GM2 (NH4+ salt), bovine

CATALOG # 1543


  • Catalog #:1543
  • Scientific Name:lyso-Monosialoganglioside GM2 (NH4+ salt), bovine
  • Common Name:lyso-GM2
  • Empirical Formula:C49H87N3O25 • NH3 (d18:1 sphingoid base)
  • CAS#:94458-61-4
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1118+ NH3 (d18:1 sphingoid base)
  • Unit:500 µg
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Natural Source:bovine
  • Solubility:chloroform/methanol/DI water, (2:1:0.1); forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application notes:

As this product is derived from a natural source, there may be variations in the sphingoid backbone.

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 GM2 regulates the function of ciliary neurotrophic factor receptors. The accumulation of GM2 (due to a deficiency in beta-hexosaminidase) has characterized Tay-Sachs disease (due to a mutation in the gene HEXA) and Sandhoff disease (due to a mutation in the gene HEXB).4 lyso-GM2 was also found in elevated amounts in brains with Sandhoff and Tay-Sachs disease. Although the origin of lyso-GM2 remains unknown, it is tied with the loss of HEXA. In a study that subjected lyso-GM2 to modified beta-hexasaminidase (Hex B) which hydrolyzes GM2 and associated gangliosides, Hex B was found to strongly influence the lyso-GM2 levels to decrease.5

Selected References:
1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002
3. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003
4. R. Gravel et al., The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001
5. T. Kodama, T. Togawa, et. al. “lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease” PLoS ONE, Vol 6, No. 12, 2011
Price $713.00

Others Also Bought

Catalog #:

Customer Reviews

Average Rating
Sign up for news & updates! Sign up!
Please Wait... processing