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TLC Sphingolipid Mixture

CATALOG # 1128

Specifications

  • Catalog #:1128
  • Scientific Name:Sphingolipid Mixture (quantitative)
  • Common Name:Sphingolipid Mixture (quantitative)
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:mixture
  • Unit:25 mg/ml, 1ml
  • Solvent:chloroform/methanol 2:1
  • Source:natural
  • Purity:mixture
  • Analytical Methods:TLC
  • Natural Source:bovine
  • Solubility:chloroform/methanol 2:1
  • Physical Appearance:liquid
  • Storage:-20°C
  • Composition:
    This is, by weight, an equal component mix of:
    cerebrosides, sulfatides and sphingomyelin
  • Dry Ice:No
  • Hazardous:Yes

Description

Application Notes:

This sphingolipid mixture contains three lipids that are critical to neuronal membrane function and comprise most of the myelin sheath of neurons. Sulfatide is a type of sulfolipid that is found primarily in the central nervous system and is a myelin-specific sphingolipid. A deficiency of sulfatide in white and gray matter has been associated with Alzheimer’s disease and other types of dementia.1 Galactocerebrosides are found primarily in neuronal tissues and are the major glycosphingolipids in the central nervous system. They are the largest single component of the myelin sheath of nerves and seem to act, along with other molecules, to form part of the structural support of the myelin sheath.2 Sphingomyelin is found in mammalian cell membranes, especially in the membranes of the myelin sheath and is involved in signal transduction and apoptosis.3 This standard is for the qualitative identification and quantitation of unknowns by TLC. All materials are analyzed to verify their identity and to determine their purity. All analytes are 98+% pure. This standard is accurately prepared by gravimetric technique (+/- 0.5%) and all glassware is class A rated. Ampules are purged with nitrogen/argon before and after filling and chilled before being flame sealed. Store ampules sealed as received and process without delay immediately after opening the ampule.

References:
1. Ramesh C. Halder, A. Jahng, I. Maricic and Vipin Kumar “Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination” Neurochemical Research, February, Vol. 32(2): 257, 2007
2. M. Sheldon, D.Lyudmila, “Cycloserine-induced decrease of cerebroside in myelin” Lipids, Vol. 33:4 pp. 441-443, 1998
3. R. N. Kolesnick, A. Haimovitz-Friedman, Z. Fuks “The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation” Biochem Cell Biol., Vol. 72(11-12) pp. 471-474, 1994
Price $150.00

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