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TLC Disialoganglioside Mixture

CATALOG # 1509

Specifications

  • Catalog #:1509
  • Scientific Name:Disialoganglioside Mixture
  • Common Name:Disialoganglioside Mixture (qualitative mixture)
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:mixture
  • Unit:0.5 mg/ml, 1ml
  • Solvent:chloroform/methanol/DI water, 2:1:0.1
  • Source:natural
  • Purity:mixture
  • Analytical Methods:TLC
  • Natural Source:bovine
  • Solubility:chloroform/methanol/DI water, 2:1:0.1
  • Physical Appearance:liquid
  • Storage:-20°C
  • Composition:GD3, GD1a, GD1b
  • Dry Ice:No
  • Hazardous:Yes

Description

Application Notes:

This product contains the disialogangliosides GD3, GD1a, and GD1b in approximately equal amounts. It is a qualitative mixture prepared from highly pure materials and is in chloroform/methanol/water (2:1:0.1). The defining characteristic of gangliosides is the sialic acid moiety of the oligosaccharide head group. This mixture contains gangliosides having two sialic acids. Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease while an autoimmune response against gangliosides can lead to Guillain-Barré syndrome. Gangliosides act as receptors for various toxins and bacteria, accumulate in different tumors, and aid in many neuronal functions. Therefore they are very important in therapeutic processes. This is a qualitative mixture and should not be used for quantitative purposes.

References:
1. L. Svennerholm et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff, “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277:29 pp. 25859-25862, 2002
3. S. Birkle et al. “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003
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