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Sphingosylphosphorylcholine

CATALOG # 1321

Specifications

  • Catalog #:1321
  • Scientific Name:Sphingosylphosphorylcholine
  • Common Name:lyso-Sphingomyelin, SPC (mixture of D-erythro, L-threo isomers)
  • Empirical Formula:C23H49N2O5P
  • CAS#82970-80-7
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:465
  • Unit:10 mg
  • Solvent:none
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC
  • Natural Source:bovine buttermilk
  • Solubility:chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

Sphingosylphosphorylcholine (SPC) is a non-acylated sphingomyelin containing a mixture of D-erythro and L-threo sphingosine isomers and is ideal for the synthesis of well-defined sphingomyelin. Sphingomyelin has a phosphorylcholine head attached to a ceramide tail and is found in mammalian cell membranes, especially in the membranes of the myelin sheath and has been linked to a number of diseases.1,2 It has been found that SPC can help devise new ways of treating inflammatory kidney diseases and has been found to trigger proteins known to reduce inflammation. SPC has also been shown to cause an increase in urine production in the kidneys with an abnormal accumulation of salt in the urine.3

References:
1. M. Schmuth, M. Q. Man, F. Weber, W. Gao, K. R. Feingold, P. Fritsch, P. M. Elias, W. M. Holleran., J Invest Dermatol, Sep;115(3):459-66, 2000
2. C. St Clair, E. R. Norwitz, K. Woensdregt, M. Cackovic, J. A. Shaw, H. Malkus, R. A. Ehrenkranz, J. L. Illuzzi., Am J Perinatol, Sep;25(8):473-80, 2008. Epub 2008 Sep 4
3. Andrea Huwiler et al., Journal of Lipid Research, Vol. 48 pp. 1985, 2007
Price $320.00

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