Application Notes:
Phosphatidylserine (PS) is a negatively charged glycerophospholipid that is widespread but quantitatively minor
phospholipid in mammalian cells. PS is found mainly in animals and white beans. PS is found mostly on the inner layer of
the plasma membrane. During cell apoptosis it is redistributed to the outer layer where it functions as a ligand for phagocyte
recognition and as an anti-inflammatory.1 In vertebrates, PS is a signal for removal by macrophages. PS is also externalized
for various cellular functions such as cell fusion, blood clotting and regulating cell signaling. It acts as an important part of
the lipid-calcium-phosphate complex needed for mineral formation.2 PS has been extensively investigated for a number of
possible therapeutic roles including treating dementia, relieving stress, and recovering from exercise.3
References:
1. Banafsheh Mirnikjoo, Krishnakumar Balasubramanian, and Alan J. Schroit, The Journal of Biological Chemistry, August, Vol. 284 pp. 22512, 2009
2. Licia N. Y. Wu, Brian R. Genge and Roy E. Wuthier, The Journal of Biological Chemistry, Feb. Vol. 283 pp.3827, 2008
3. T. H. Crook, PhD, J. Tinklenberg, MD, J. Yesavage, MD, W. Petrie, MD, M. G. Nunzi, PhD and D. C. Massari, PhD, American Academy of Neurology, Vol. 41 pp. 644, 1991