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N-Propanoyl-BODIPY-monosialoganglioside GM1 (NH4+ salt)

CATALOG # 2060

Specifications

  • Catalog #:2060
  • Scientific Name:N-Propanoyl-BODIPY-monosialoganglioside GM1 (NH4+ salt)
  • Common Name:C3:0-BODIPY-GM1; N-[3-(BODIPY)propanoyl] GM1; N-omega-BODIPY-Propanoyl GM1
  • Empirical Formula:C69H110BF2N5O31 • NH3
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1554 + NH3
  • Unit:100 ug
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:bovine
  • Solubility:chloroform/methanol/water, 2:1:0.2
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

Gangliosides1 are acidic glycosphingolipids containing sialic acids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by directly and tightly associating with Trk, the high-affinity tyrosine kinase-type receptor for NGF. It is the specific cell surface receptor for cholera toxin. The BODIPY tag will introduce a fluorescent probe into any application of GM1.

Selected References:
1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff, “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002
Price $250.00

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