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Methyl 9(Z), 11(Z)-octadecadienoate

CATALOG # 1256

Specifications

  • Catalog #:1256
  • Scientific Name:Methyl 9(Z), 11(Z)-octadecadienoate
  • Common Name:Methyl ester of CLA (9 cis, 11 cis)
  • Empirical Formula:C19H34O2
  • CAS#:822-10-6
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:294
  • Unit:25 mg
  • Source:synthetic
  • Purity:96+%
  • Analytical Methods:TLC; GC; identity confirmed by MS
  • Solubility:ethanol, methanol, hexane, chlorofrom
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

9(Z),11(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals including dairy products. It has several biological properties including anticarcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Due to its being a minor component it is very helpful as a comparison to the major isomers 9(Z),11(E)-CLA and 10(E),12(Z)-CLA. 9(Z),11(Z)-CLA has been demonstrated to have a more potent antiproliferative effect than the more common 9(Z),11(E)-CLA isomer when incubated with human colon cancer cells.

References:
1. H. MacDonald “Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge” Journal of the American College of Nutrition, Vol. 19 pp. 111S-118S, 2000
2. M. Coakley, et al. “Intestinal Bifidobacteria That Produce trans-9, trans-11 Conjugated Linoleic Acid: A Fatty Acid With Antiproliferative Activity Against Human Colon SW480 and HT-29 Cancer Cells” Nutrition and Cancer, Vol. 56:1 pp. 95-102, 2006
Price $155.00

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