CUSTOMER SERVICE  |  814.355.1030  |  Toll Free: 800.342.3595  |  M-F: 8am-4pm EST/EDT

Fucosylated monosialoganglioside GM1 (NH4+salt), porcine

CATALOG # 1526


  • Catalog #:1526
  • Scientific Name:Fucosylated monosialoganglioside GM1 (NH4+salt), porcine
  • Common Name:Fucosyl-GM1
  • Empirical Formula:C79H141N3O35•NH3 (stearoyl; d18:1 sphingoid base)
    Typical fatty acid content
  • CAS#:71812-11-8
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1693 + NH3 (stearoyl; d18:1 sphingoid base)
  • Unit:500 ug
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:porcine
  • Solubility:chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

As this product is derived from a natural source, there may be variations in the sphingoid backbone.

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. Fucosyl-GM1 is a tumor associated ganglioside and is an antigen expressed in small cell lung cancer that is being investigated as a target for vaccines against cancer cells.3 It has been found that Fucosyl-GM1 demonstrates some of the same binding properties as the similar GM1 ganglioside such as affinity for cholera toxin B subunit and interaction with amyloid-beta protein.4

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
3. G. Ragupathi et al. “Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells” Cancer Immunology, Immunotherapy, Vol. 48 pp. 483-492, 1999
4. M. Yanagisawa, T. Ariga, R. Yu “Fucosyl-GM1 expression and amyloid-ß protein accumulation in PC12 cells” Journal of Neuroscience Research, Vol. 84 pp. 1343-1349, 2006
Price $708.00

Others Also Bought

Catalog #:
Catalog #: 1061
CAS#: 37758-47-7
Unit: 5 mg
Catalog #: 1501
CAS#: 19553-76-5
Unit: 1 mg

Customer Reviews

Average Rating
Sign up for news & updates! Sign up!
Please Wait... processing