D-erythro-Sphingosine

CATALOG # 1802
Amount 25 mg
Price $95.00
Qty
 
D-erythro-Sphingosine
  • Catalog #:1802
  • Scientific Name:D-erythro-Sphingosine
  • Common Name:Sphingosine, C18 chain; (2S,3R)-D-erythro-2-amino-1,3-Octadec-4E-enediol
  • Empirical Formula:C18H37NO2
  • CAS#123-78-4
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:299
  • Unit:25 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC, identity confirmed by MS
  • Solubility:chloroform, ethanol, methanol, DMSO
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others.1,2 It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18-carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. Lysosphingolipids inhibit protein kinase C activity resulting in the pathogenesis of sphingolipidoses such as Krabbe's disease and Gaucher's disease.3 Sphingosine can be phosphorylated via two kinases to form sphingosine-1-phosphate, which has important signaling functions. While sphingosines and ceramides can induce apoptosis,4 sphingosine-1-phosphate can promote cell survival or proliferation. Sphingosine has been shown to cause an increase in the cytoplasmic calcium level of cells.

    References:
    1. A. Merrill, Jr., The Journal of Biological Chemistry, Vol. 277(29) pp. 25843–25846, 2002
    2. J. Shayman, Kidney International, Vol. 58 pp. 11-26, 2000
    3. Y. Hannun and R. Bell, Vol. 235:4789 pp. 670, 1987
    4. V. Nava et al., Cancer Research, Vol. 60 pp. 4468-4474, 2000