CATALOG # 1802
Amount 25 mg
Price $95.00
  • Catalog #:1802
  • Scientific Name:D-erythro-Sphingosine
  • Common Name:Sphingosine, C18 chain; (2S,3R)-D-erythro-2-amino-1,3-Octadec-4E-enediol
  • Empirical Formula:C18H37NO2
  • CAS#123-78-4
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:299
  • Unit:25 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC, identity confirmed by MS
  • Solubility:chloroform, ethanol, methanol, DMSO
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others.1,2 It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18-carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. Lysosphingolipids inhibit protein kinase C activity resulting in the pathogenesis of sphingolipidoses such as Krabbe's disease and Gaucher's disease.3 Sphingosine can be phosphorylated via two kinases to form sphingosine-1-phosphate, which has important signaling functions. While sphingosines and ceramides can induce apoptosis,4 sphingosine-1-phosphate can promote cell survival or proliferation. Sphingosine has been shown to cause an increase in the cytoplasmic calcium level of cells.

    1. A. Merrill, Jr., The Journal of Biological Chemistry, Vol. 277(29) pp. 25843–25846, 2002
    2. J. Shayman, Kidney International, Vol. 58 pp. 11-26, 2000
    3. Y. Hannun and R. Bell, Vol. 235:4789 pp. 670, 1987
    4. V. Nava et al., Cancer Research, Vol. 60 pp. 4468-4474, 2000