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Cholesterol-beta-D-glucoside

CATALOG # 1940

Specifications

  • Catalog #:1940
  • Scientific Name:Cholesterol-beta-D-glucoside
  • Common Name:Cholesteryl-beta-D-glucopyranoside
  • Empirical Formula:C33H56O6
  • CAS#7073-61-2
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:549
  • Unit:5 mg
  • Solvent:none
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC; HPLC; identity confirmed by MS
  • Natural Source:plant
  • Melting Point:n/a
  • Solubility:chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

The physiological significance of the glucosylation of cholesterol is to render cholesterol far more water soluble and usable for transportation within a cell.1 Parkinsonism and glucosylceramide metabolism appear to be linked given the high incidence of neurodegenerative conditions in patients with Gaucher disease, a lysosomal storage disorder.2 It may be speculated that glucosylceramide acts as a donor in the biosynthesis of the potentially neurotoxic steryl-β-glucosides, implying that cholesteryl-β-glucoside is a missing link between parkinsonism and Gaucher.3

References:
1. Westbroek, W.; Gustafson, A. M.; Sidransky, E. Trends Mol. Med. 2011, 286, 28080–28088.
2. A. R. A. Marques,et al. “Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular-glucosidases” Journal of Lipid Research, vol. 57 pp. 451-463, 2016
3. “Synthesis of α- and β-Cholesteryl Glucosides.” Chapter 6. Retrieved from https://openaccess.leidenuniv.nl/bitstream/handle/1887/18246/06.pdf?sequence=8
Price $150.00

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