Anti-ganglioside GD2 (polyclonal antibody)

CATALOG # 1963
Amount 50 µl
Price $390.00
Anti-ganglioside GD2 (polyclonal antibody)
  • Catalog #:1963
  • Scientific Name:Anti-ganglioside GD2 (polyclonal antibody)
  • Common Name:Anti-ganglioside GD2 (polyclonal antibody)
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:n/a
  • Unit:50 µl
  • Solvent:none
  • Source:rabbit
  • Purity:serum, not purified
  • Analytical Methods:ELISA, TLC immunoblotting
  • Natural Source:rabbit
  • Solubility:water
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:Yes
  • Hazardous:No
  • Literature References:Application Notes:

    Anti-ganglioside GD2 (anti-GD2) is very useful in the identification of disialoganglioside GD2 and in immunotargeting cells expressing disialoganglioside GD2. Several gangliosides have been found to have elevated expressions in tumor cells. Many therapeutic treatments of tumor cells are being investigated using antibodies to target cells that express these elevated levels of gangliosides. Disialoganglioside GD2 has been identified as a tumor-associated antigen and therapeutic approaches using anti-GD2 are being investigated and show great potential.1 Although many challenges must still be overcome in using this therapeutic approach progress is steadily going forward.2

    Selected References:
    1. M. Ozkaynak et al. “Phase I Study of Chimeric Human/Murine Anti–Ganglioside GD2 Monoclonal Antibody (ch14.18) With Granulocyte-Macrophage Colony-Stimulating Factor in Children With Neuroblastoma Immediately After Hematopoietic Stem-Cell Transplantation: A Children’s Cancer Group Study” Journal of Clinical Oncology, Vol 18(24) pp. 4077-4085, 2000
    2. J. Hu et al. “Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody” The Journal of Immunology, Vol. 186(4) pp. 1-8, 2009