2-Hydroxytetracosanoic acid

CATALOG # 1715
Amount 5 mg
Price $220.00
Qty
 
2-Hydroxytetracosanoic acid
  • Catalog #:1715
  • Scientific Name:2-Hydroxytetracosanoic acid
  • Common Name:2-Hydroxylignoceric; 2-Hydroxy C24:0 fatty acid; Cerebronic acid
  • Empirical Formula:C24H48O3
  • CAS#544-57-0
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:385
  • Unit:5 mg
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC, identity confirmed by MS
  • Melting Point:101-104°C
  • Solubility:chloroform/methanol, 5:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    alpha-Hydroxy very long chain fatty acids are abundant in nervous tissues and are components of cerebrosides and sulfatides, which are mostly found in myelin of nervous tissues. 2-Hydroxytetracosanoic acid, which is unique to nervous tissues, is formed by the oxidation of tetracosanoic acid by the enzyme fatty acid 2-hydroxylase. This enzyme is also responsible for the formation of 2-hydroxy galactolipids in the peripheral nervous system.1 alpha-Oxidation of 2-hydroxytetracosanoic acid to CO2 and tricosanoic acid occurs in the peroxisome and is unique from the alpha-oxidation of beta-carbon branched fatty acids such as phytanic acid. Cells from Zellweger syndrome and peroxisome-deficient cells are unable to undergo alphaoxidation although patients with other peroxisomal disorders such as X-linked adrenoleukodystrophy, Refsum disease, and rhizomelic chondrodysplasia punctata were able to.2 2-Hydroxytetracosanoic acid is undergoing much research and various methods of analysis are being investigated.3

    References:
    1. E. Maldonado et al. “FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin” Journal of Lipid Research, Vol. 49 pp. 153-161, 2008
    2. R. Sandhir, M. Khan, and I. Singh “Identification of the Pathway of alpha -Oxidation of Cerebronic Acid in Peroxisomes” Lipids, Vol. 35(10) pp. 1127-1133, 2000
    3. N. Alderson, M.Walla, and H. Hama “A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry” Journal of Lipid Research, Vol. 46 pp. 1569-1579, 2005