Application Notes:
10(E),12(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in
lipids originating in ruminant animals, including dairy products. It has several biological properties including anticarcinogenic
activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting
anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances
which protect cells from the detrimental effects of peroxides. Animals fed a diet containing high levels of CLA have been
observed to have improved feed efficiency (lean body mass increased while body fat decreased) and this seems to be due,
mainly or exclusively, to the 10(E),12(Z)-Octadecadienoic acid.2 However, this isomer appears to increase oxidative stress
and inflammatory biomarkers in obese men, which can lead to insulin resistance.3,4 10(E),12(Z)-Octadecadienoic acid
increases LDL:HDL cholesterol and total:HDL cholesterol in humans.
References:
1. Helen B. MacDonald, Journal of the American College of Nutrition, Vol. 19, No. 90002, 111S-118S, 2000
2. Yanwen Wang and Peter J. H. Jones, The American Journal of Clinical Nutrition, June, Vol. 79, No. 6, 1153S-1158S, 2004
3. Ulf Risérus, MMed, Samar Basu, PhD; Stefan Jovinge, MD, PhD; Gunilla Nordin Fredrikson, PhD; Johan Ärnlöv, MD; Bengt Vessby, MD, PhD, Circulation, 106:1925, 2002
4. Soonkyu Chung, J. Mark Brown, J. Nathan Provo, Robin Hopkins and Michael K. McIntosh, The Journal of Biological Chemistry, September, Vol. 280: 38445, 2005