Biotinylated Glycosphingolipids

Matreya’s line of biotinylated sphingolipids are ideal for use in sphingolipid research; they take advantage of the strong and specific interaction of biotin with streptavidin and avidin proteins. These sphingolipid analogs contain a biotin label attached to the amine of the sphingosine moiety via a hexanoic acid linker which maintains the sphingolipid’s natural properties. The interaction with streptavidin and avidin proteins makes them extremely useful for binding to substrates,¹ ELISA testing,² and for toxin detection.

References:

1. A. Mukhopadhyay et al., "Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling" FASEB, Vol. 23(3) pp. 751-763, 2009
2. A. Pukin et al., "Chemoenzymatic synthesis of biotin-appended analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a for solid-phase applications and improved ELISA tests" Org. Biomol. Chem., Vol. 9(16) pp. 5809-5815, 2011