CUSTOMER SERVICE  |  814.355.1030  |  Toll Free: 800.342.3595  |  M-F: 8am-4pm EST/EDT

Gangliosides

Gangliosides are acidic glycosphingolipids that contribute a substantial presence to the outer leaflet of the cell plasma membrane. This is especially apparent in neuronal cells of the central nervous system where they have vital roles as neurotransmitters and cellular regulators.1 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 Gangliosides have been implicated in numerous types of cancer where they are often over-expressed on the membrane surface.3 A deficiency in the enzymes responsible for metabolizing gangliosides causes toxic levels of ganglioside accumulation which is indicative of several lysosomal storage diseases, including GM1 gangliosidosis, GM2 gangliosidosis, Tay-Sachs disease, and Sandhoff disease. Matreya now offers a number of high purity deuterated gangliosides which are ideal for mass spectrometry studies.4

References:

  1. T. Kolter "Ganglioside Biochemistry" International Scholarly Research Network, Vol. 2012 pp. 1-36, 2012
  2. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry "Role of tumor-associated gangliosides in cancer progression" Biochimie, Vol. 85 pp. 455-463, 2003
  3. P. Giussani et al., "Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance" International Journal of Molecular Sciences, Vol. 15 pp. 4356-4392, 2014
  4. J. Gu, C. Tifft and S. Soldin "Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometry" Clinical Biochemistry, Vol. 41(6) pp. 413-417, 2008

Catalog #: 1064
CAS# 71012-19-6
Unit: 1 mg
$390.00
Catalog #: 1512
CAS# 35960-33-9
Unit: 100 µg
$630.00
Catalog #: 1526
CAS# 71812-11-8
Unit: 500 ug
$595.00
Catalog #: 1061
CAS# 37758-47-7
Unit: 5 mg
$315.00
Catalog #: 1061-50
CAS# 37758-47-7
Unit: 50 mg
$2,450.00
Catalog #: 1518
CAS# 171483-40-2
Unit: 500 µg
$390.00
Catalog #: 2050
CAS#
Unit: 500 µg
$550.00
Catalog #: 2053
CAS#
Unit: 500 µg
$575.00
Catalog #: 1542
CAS# 19600-01-2
Unit: 1 mg
$450.00
Catalog #: 1502
CAS# 19600-01-2
Unit: 500 µg
$335.00
Catalog #: 2051
CAS#
Unit: 250 ug
$490.00
Catalog #: 1503
CAS# 54827-14-4
Unit: 1 mg
$175.00
Catalog #: 2052
CAS#
Unit: 250 ug
$410.00
Catalog #: 2056
CAS#
Unit: 500 µg
$575.00
Catalog #: 1535
CAS# 66456-69-7
Unit: 500 µg
$450.00
Catalog #: 1062
CAS# 12707-58-3
Unit: 5 mg
$235.00
Catalog #: 1501
CAS# 19553-76-5
Unit: 1 mg
$285.00
Catalog #: 1527
CAS# 65988-71-8
Unit: 500 µg
$665.00
Catalog #: 1504
CAS# 62010-37-1
Unit: 5 mg
$315.00
Catalog #: 1504-25
CAS# 62010-37-1
Unit: 25 mg
$925.00
Sign up for news & updates! Sign up!
Please Wait... processing