Enzyme Inhibitors

Matreya offers inhibitors that will stop the enzymatic metabolism of glycolipids at various points in their biosynthetic routes. PDMP and PPMP are well known inhibitors of glucosylceramide synthase and both active and inactive isomers are available for comparison studies.1 Safingol is an important inhibitor of protein kinase C which controls the function of proteins through phosphorylation. Acid and alkaline ceramidase inhibitors, including NOE and D-MAPP, prevent the metabolism of ceramide to sphingosine.2 Conduritol B epoxide inhibits glucosidase activity and is commonly used to produce a model of Gaucher disease.3 A new class of inhibitors containing adamantane functional groups have opened up new routes of research into enzyme manipulation.4


  1. N. Radin, et al., “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995
  2. C. Rodriguez-Lafrasse et al. “Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing” International Journal of Cancer, Vol. 101 pp. 589-598, 2002
  3. L. Premkumar et al. “X-ray Structure of Human Acid-beta-Glucosidase Covalently Bound to Conduritol-B-Epoxide Implications for Gaucher Disease” The Journal of Biological Chemistry, Vol. 280(25) pp. 23815-23819, 2005
  4. C. Lingwood et al. “Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism” The Journal of Biological Chemistry, Vol. 286(24) pp. 21413-21426, 2011