Biotinylated Standards

Matreya’s new line of biotinylated sphingolipids are ideal for use in sphingolipid research, taking advantage of the strong and specific interaction of biotin with streptavidin/avidin. These sphingolipid analogs contain a biotin label attached to the amine of the sphingosine moiety via a hexanoic acid linker which maintains the sphingolipid’s natural properties. The biotin label allows for easy attachment of the sphingolipid to streptavidin/avidin proteins. This attachement makes them extremely useful for binding to substrates,1 ELISA testing,2 and for toxin detection. Matreya’s biotinylated products have a natural ceramide backbone to maintain its natural properties and a biotin label for very specific streptavidin/avidin binding.

References:

  1. A. Mukhopadhyay et al., "Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling" FASEB, Vol. 23(3) pp. 751-763, 2009
  2. A. Pukin et al., "Chemoenzymatic synthesis of biotin-appended analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a for solid-phase applications and improved ELISA tests" Org. Biomol. Chem., Vol. 9(16) pp. 5809-5815, 2011

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N-Hexanoyl-biotin-D-erythro-sphingosine

N-Hexanoyl-biotin-D-erythro-dihydrosphingosine

N-Hexanoyl-biotin-phytosphingosine

N-Hexanoyl-biotin-galactosylceramide

N-Hexanoyl-biotin-glucosylceramide

N-Hexanoyl-biotin-sulfatide

N-Hexanoyl-biotin-lactosylceramide

N-Hexanoyl-biotin-monosialoganglioside GM1

N-Hexanoyl-biotin-disialoganglioside GD3