N-Dodecanoyl-NBD-ceramide trihexoside

  • Catalog #: 1631
  • Scientific Name: N-Dodecanoyl-NBD-ceramide trihexoside
  • Common Name: N-C12:0-NBD-CTH; N-C12:0-NBD-Globotriaosylceramide
  • Empirical Formula: C54H91N5O21
  • SDS View Safety Data Sheet
  • Data Sheet: View Data Sheet
  • Formula Weight: 1145
  • Unit: 100 ug
  • Solvent: none
  • Source: semisynthetic
  • Purity: 98+%
  • Analytical Methods: TLC
  • Natural Source: porcine RBC
  • Solubility: DMSO, hot methanol, chloroform/methanol, 2:1
  • Physical Appearance: solid
  • Storage: -20°C
  • Dry Ice: No
  • Hazardous: No
  • Literature References: 
    1. J. Kok et al. “Dihydroceramide Biology STRUCTURE-SPECIFIC METABOLISM AND INTRACELLULAR LOCALIZATION” Journal of Biological Chemistry, Vol. 272 pp. 21128-21136, 1997
    2. J. Hsu et al. “Enhanced endothelial delivery and biochemical effects of -galactosidase by ICAM-1-targeted nanocarriers for Fabry disease” Journal of Controlled Release, doi:10.1016/j.jconrel.2010.10.031, 2010
    3. J. E. Groener, B. J. Poorthuis, S. Kuiper, M. T. Helmond, C. E. Hollak, J. M. Aerts. “HPLC for simultaneous quantification of total ceramide, glucosylceramide, and ceramide trihexoside concentrations in plasma.” Clin Chem., Apr;53(4):742-7, 2007. Epub Mar 1 2007
    4. K. Mills, A. Johnson, B. Winchester. “Synthesis of novel internal standards for the quantitative determination of plasma ceramide trihexoside in Fabry disease by tandem mass spectrometry.” FEBS Lett., Mar 27;515(1-3):171-6, 2002
    5. C. Menge, I. Stamm, M. Wuhrer, R. Geyer, L. H. Wieler, G. Baljer. “Globotriaosylceramide (Gb(3)/CD77) is synthesized and surface expressed by bovine lymphocytes upon activation in vitro.” Vet Immunol Immunopathol., Nov;83(1-2):19-36, 2001
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